Southern Medical Journal - DONEPEZIL (ARICEPT).(Brief Article)
MODE OF ACTION
Reversible Cholinesterase Inhibitor
Preferential inhibition of acetyicholinesterase in the central nervous system.
Increases concentration of acetylcholine by preventing its hydrolysis by cholinesterase.
Result is improved cholinergic transmission of nerve impulses.
EFFECTS ON ALZHEIMER’S DISEASE
Used to treat mild to moderate Alzheimer’s disease.
Benefits of therapy are modest and transient.
Improvement in or stabilization of cognitive functioning may be seen in up to 89% of patients.
CONTRAINDICATIONS
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